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Globally, cancer of the colon and rectum is the third leading cause of cancer in males and the fourth leading cause of cancer in females. It is common in the Western world and is rare in Asia and Africa. The frequency of colorectal cancer varies around the world. In countries where western diets are adopted and are believed to have high fat intake, the incidence of colorectal cancer increases.
Diets high in fat are believed to predispose humans to colorectal cancer. It is believed that the breakdown products of fat metabolism lead to the formation of cancer-causing chemicals (carcinogens). Diets high in vegetables and high-fiber foods such as whole-grain breads and cereals may rid the bowel of these carcinogens and help reduce the risk of cancer.